Peer-reviewed veterinary case report
Vincristine stops tumor growth and triggers cell death in dogs
By Özalp, G R et al.Ā·Published in Biotechnic & histochemistry : official publication of the Biological Stain CommissionĀ·2012Ā·Department of Obstetrics and GynecologyĀ·View original on PubMed ā
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research ā every detail traces back to the citation above. How we work ā
Original publication title: Vincristine modulates the expression of Ki67 and apoptosis in naturally occurring canine transmissible venereal tumor (TVT).
- Species:
- dog
Plain-English summary
Eight adult dogs with transmissible venereal tumors (TVT) were treated with vincristine, a chemotherapy drug, to see how it affected the tumors. After starting treatment, the tumors showed a decrease in cell growth and an increase in cell death, which is a good sign that the tumors were responding to the medication. The results indicated that vincristine effectively helped shrink the tumors by stopping them from growing and encouraging the cancer cells to die.
People also search for: dog cancer treatment vincristine Ā· transmissible venereal tumor in dogs Ā· chemotherapy for dog tumors
Abstract
We investigated eight adult dogs that were brought to veterinary clinics with a history of transmissible venereal tumors (TVT). Our goal was to demonstrate the occurrence of apoptosis and the cessation of cell proliferation at every phase of scheduled chemotherapy for naturally occurring TVT. Tissue samples were collected immediately after weekly treatments with vincristine sulfate and processed for histological purposes. Sections 5 μm thick were stained by the TUNEL reaction for apoptosis and immunostained for Ki67 as a proliferation marker. We observed that after vincristine applications, tumor cell proliferation ceased and apoptosis increased. Ki67 HSCORE values were significantly lowered after the first and second treatments with the chemotherapeutic agent compared to controls, whereas TUNEL HSCORE values were significantly higher after two applications of vincristine compared to controls. Our results suggest that scheduled vincristine sulfate applications stabilize the induction of tumor regression by inducing apoptosis and preventing cell proliferation.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22404564/