Peer-reviewed veterinary case report
Vincristine sulfate as single-agent chemotherapy in a dog and a cat with malignant neoplasms.
- Journal:
- Journal of the American Veterinary Medical Association
- Year:
- 1990
- Authors:
- Hahn, K A
- Affiliation:
- Department of Veterinary Clinical Sciences
- Species:
- cat
Plain-English summary
A 12-year-old spayed female cat weighing about 4 kg had a type of cancer called fibrosarcoma, which was located in her jaw. An 11-year-old castrated male dog, weighing around 13 kg, had another type of cancer called hemangiosarcoma that had spread to his lungs. Both pets were treated with a chemotherapy drug called vincristine sulfate, given through an IV once a week. After three months of treatment, both the cat and the dog showed no signs of their cancers. This suggests that vincristine sulfate can be an effective treatment for these specific types of cancer in pets.
Abstract
A 12-year-old 4-kg spayed domestic shorthair cat with a poorly differentiated fibrosarcoma of the rostral aspect of the mandible and an 11-year-old 13-kg castrated dog of mixed breeding with pulmonary metastatic hemangiosarcoma were treated with 0.5 mg of vincristine sulfate/m2 of body surface, IV, weekly. Three months after beginning treatment, both animals had complete clinical remission. The role of this vinca alkaloid as a single agent for malignant neoplasms has seldom been discussed in the veterinary scientific literature. The results of these two cases indicate that single-agent vincristine sulfate chemotherapy is effective in the treatment of feline fibrosarcoma and canine hemangiosarcoma.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/2211297/