Peer-reviewed veterinary case report
VIRAL PLASMACYTOSIS (ALEUTIAN DISEASE) IN MINK. V. THE OCCURRENCE OF HYALIN GLOMERULAR LESIONS AND FIBRINOID ARTERITIS IN EXPERIMENTAL INFECTIONS.
- Journal:
- Canadian journal of comparative medicine and veterinary science
- Year:
- 1965
- Authors:
- KARSTAD, L
Plain-English summary
In a study involving 100 mink infected with a virus that causes viral plasmacytosis (a disease that affects blood cells), researchers looked for specific damage in the blood vessels. They found abnormal deposits in the kidneys of all the mink with advanced disease, and a type of blood vessel inflammation called fibrinoid arteritis was seen in some Aleutian mink (a specific breed) that had severe disease. Out of 30 Aleutian mink tested, seven had this blood vessel inflammation along with other serious health issues. The way the virus was introduced didn't seem to affect the severity of the damage. Overall, the findings support the idea that this virus is a major cause of the disease and suggest that Aleutian disease can be useful for studying related health issues.
Abstract
One hundred mink with experimental viral plasmacytosis were examined for fibrinoid vascular lesions. Abnormal hyalin deposits were found in glomeruli in all cases of advanced disease. Fibrinoid arteritis occurred only in Aleutian type mink in this study. Seven of 30 experimentally infected Aleutian mink were found to have fibrinoid arteritis, together with other lesions of advanced plasmacytosis. The type of inoculum seemed of no consequence in development of vascular lesions. Equally severe lesions developed after inoculation with cell-free filtrates as were found in mink inoculated with crude tissue suspensions. These observations strengthen the concept of a virus as the primary etiologic agent and confirm the view that Aleutian disease is a convenient experimental model for studies on the collagen diseases.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/14299494/