Peer-reviewed veterinary case report
Dog diarrhea linked to mammalian orthoreovirus type 3 in Italy
By Decaro, Nicola et al.·Published in Veterinary microbiology·2005·Department of Animal Health and Well-being, Italy·View original on PubMed →
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Original publication title: Virological and molecular characterization of a mammalian orthoreovirus type 3 strain isolated from a dog in Italy.
- Species:
- dog
Plain-English summary
A puppy in Italy was diagnosed with severe diarrhea and unfortunately passed away. Tests revealed that the pup had a mammalian orthoreovirus type 3 (MRV-3) infection alongside canine parvovirus type 2. Researchers confirmed the presence of MRV-3 through specific genetic tests. Although the study found no other dogs with MRV in a larger sample, a significant number of dogs showed antibodies against the virus, indicating it might be present in the population.
People also search for: puppy diarrhea causes · canine parvovirus treatment · dog viral infections · MRV-3 in dogs · puppy fatal diarrhea symptoms
Abstract
A mammalian orthoreovirus (MRV) strain was isolated from a pup with fatal diarrhea, which had a concurrent infection by canine parvovirus type 2. The reovirus isolate showed an atypical hemagglutination pattern and a retarded electrophoretic mobility of the S1 segment, which is characteristic of MRV type 3 (MRV-3). Assignment of the isolated virus to MRV-3 was confirmed by type-specific RT-PCR assays, targeting the S1 gene, and by subsequent sequence analysis of the PCR product. By phylogeny based on the S1 gene of several MRVs, the isolate fell into lineage E, along with the murine strain T3C9/61 and the bovine strains T3C18/61 and T3C31/59. Conversely, L1 sequences were found to segregate regardless of the viral type. A total of 110 fecal samples, 56 nasal and 31 ocular swabs from dogs with diarrhea or nasal/ocular discharge were tested by a nested-PCR assay specific for reoviruses, and no sample was found to contain MRV RNA, a finding that is apparently in contrast with the seroprevalence (25.77%) observed in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15964158/