Peer-reviewed veterinary case report
Vitamin E does not improve anemia or oxidative stress in cats
By Timmons, Rebecca M. & Webb, Craig B.·Published in Veterinary Medicine and Science·2016·Department of Clinical Sciences College of Veterinary Medicine and Biomedical Sciences Colorado State University Fort Collins CO 80523, United States·View original on Crossref →
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Original publication title: Vitamin E supplementation fails to impact measures of oxidative stress or the anaemia of feline chronic kidney disease: a randomised, double‐blinded placebo control study
- Species:
- cat
Plain-English summary
A group of 36 cats with chronic kidney disease (CKD) were given either vitamin E or a placebo for three months to see if it would help reduce oxidative stress and improve their anemia. After the treatment, the researchers found no significant differences in blood tests or health measures between the two groups. This means that the vitamin E did not help these cats maintain healthier red blood cells or reduce oxidative stress related to their kidney disease. Unfortunately, daily vitamin E supplementation did not provide any benefits for these cats.
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Abstract
Abstract This study was designed to test the hypothesis that supplementation with vitamin E, an antioxidant, in cats with chronic kidney disease ( CKD ), would reduce oxidative stress and its impact on RBC membrane fragility, resulting in these cats maintaining a greater packed cell volume ( PCV ) compared with CKD cats not receiving supplementation. Thirty‐six cats with CKD were randomly assigned to receive either daily vitamin E or a placebo for 3 months in a double‐blinded study design. History and physical examination, blood pressure, complete blood count ( CBC ), PCV , biochemical profile and urinalysis ( UA ) were determined. Parameters of oxidative stress and osmotic fragility were measured. Cats were administered vitamin E or placebo once daily for 3 months. Cats were then reassessed and the diagnostics were repeated. Twenty‐four cats completed the study, 11 in the vitamin E group and 13 in the placebo group. There were no significant differences between the two groups at the start, or upon completion of the study with regard to biochemical parameters, oxidative stress, erythrocyte osmotic fragility or PCV . None of these parameters changed significantly in either group over the treatment period. Daily supplementation with 30 IU of vitamin E did not affect the measures of oxidative stress or the anaemia seen in cats with CKD .
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Search related cases →Original publication on Crossref: https://doi.org/10.1002/vms3.21