Peer-reviewed veterinary case report
Voltage-dependent ion channels in the mouse RPE: comparison with Norrie disease mice.
- Journal:
- Vision research
- Year:
- 2006
- Authors:
- Wollmann, Guido et al.
- Affiliation:
- Institut fuer Klinische Physiologie · Germany
- Species:
- rodent
Abstract
We studied electrophysiological properties of cultured retinal pigment epithelial (RPE) cells from mouse and a mouse model for Norrie disease. Wild-type RPE cells revealed the expression of ion channels known from other species: delayed-rectifier K(+) channels composed of Kv1.3 subunits, inward rectifier K(+) channels, Ca(V)1.3 L-type Ca(2+) channels and outwardly rectifying Cl(-) channels. Expression pattern and the ion channel characteristics current density, blocker sensitivity, kinetics and voltage-dependence were compared in cells from wild-type and Norrie mice. Although no significant differences were observed, our study provides a base for future studies on ion channel function and dysfunction in transgenic mouse models.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16289664/