Peer-reviewed veterinary case report
Water-soluble PDE4 inhibitors for the treatment of dry eye.
- Journal:
- Bioorganic & medicinal chemistry letters
- Year:
- 2010
- Authors:
- Govek, Steven P et al.
- Affiliation:
- Kalypsys · United States
Abstract
PDE4 inhibitors have the potential to alleviate the symptoms and underlying inflammation associated with dry eye. Disclosed herein is the development of a novel series of water-soluble PDE4 inhibitors. Our studies led to the discovery of coumarin 18, which is effective in a rabbit model of dry eye and a tear secretion test in rats.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/20378348/