Peer-reviewed veterinary case report
Water soluble prodrug of a COX-2 selective inhibitor suitable for intravenous administration in models of cerebral ischemia.
- Journal:
- Bioorganic & medicinal chemistry letters
- Year:
- 2005
- Authors:
- Smith, Nicholas D et al.
- Affiliation:
- Department of Medicinal Chemistry · United States
- Species:
- rodent
Abstract
A water soluble choline prodrug (17) of a COX-2 selective inhibitor (16) suitable for intravenous dosing in models of cerebral ischemia has been developed. Constant infusion studies using 17 demonstrate that extrapolated brain levels of 16 may be maintained for over 24h in rats.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15936193/