Peer-reviewed veterinary case report
We need to talk about lung cancer's cholesterol-hoarding problem.
- Journal:
- Cell stem cell
- Year:
- 2023
- Authors:
- Fessler, Michael B
- Affiliation:
- National Institute of Environmental Health Sciences · United States
Abstract
Proliferative cells require excess cholesterol to support rapid membrane biogenesis. Using a mutant KRAS mouse model of non-small cell lung cancer, Guilbaud et al. show that lung cancers accumulate cholesterol by locally and distally reprogramming lipid trafficking and that cholesterol-removing interventions may hold promise as a therapeutic strategy.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/37267910/