Peer-reviewed veterinary case report
What's wrong with my mouse model? Advances and strategies in animal modeling of anxiety and depression.
- Journal:
- Behavioural brain research
- Year:
- 2007
- Authors:
- Kalueff, A V et al.
- Affiliation:
- National Institute of Mental Health · United States
Abstract
Stress plays a key role in pathogenesis of anxiety and depression. Animal models of these disorders are widely used in behavioral neuroscience to explore stress-evoked brain abnormalities, screen anxiolytic/antidepressant drugs and establish behavioral phenotypes of gene-targeted or transgenic animals. Here we discuss the current situation with these experimental models, and critically evaluate the state of the art in this field. Noting a deficit of fresh ideas and especially new paradigms for animal anxiety and depression models, we review existing challenges and outline important directions for further research in this field.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17306892/