Peer-reviewed veterinary case report
Whole blood cells loaded with messenger RNA as an anti-tumor vaccine.
- Journal:
- Advanced healthcare materials
- Year:
- 2014
- Authors:
- Phua, Kyle K L et al.
- Affiliation:
- Department of Chemical & Biomolecular Engineering · United States
- Species:
- rodent
Abstract
The use of a cell-based vaccine composed of autologous whole blood cells loaded with mRNA is described. Mice immunized with whole blood cells loaded with mRNA encoding antigen develop anti-tumor immunity comparable to DC-RNA immunization. This approach offers a simple and affordable alternative to RNA-based cellular therapy by circumventing complex, laborious and expensive ex vivo manipulations required for DC-based immunizations.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24339387/