Peer-reviewed veterinary case report
Winnie-Mice: A Spontaneous Model of Colitis-Associated Colorectal Cancer Combining Genetics and Inflammation.
- Journal:
- International journal of molecular sciences
- Year:
- 2020
- Authors:
- De Santis, Stefania et al.
- Affiliation:
- Department of Pharmacy-Drug Science · Italy
- Species:
- rodent
Abstract
(1) Background: Colorectal cancer (CRC) is among the best examples of the relationship between inflammation and increased cancer risk. (2) Methods: To examine the effects of spontaneous low-grade chronic inflammation on the pathogenesis of CRC, we developed a new murine model of colitis-associated cancer (CAC) by crossing Mucin 2 mutated mice (Winnie) withmice. (3) Results: The resulting Winnie-model combines an inflammatory background with a genetic predisposition to small intestinal polyposis. Winnie-mice show an early occurrence of inflammatory signs and dysplastic lesions in the distal colon with a specific molecular signature. (4) Conclusion: The Winnie-model is a perfect model to demonstrate that chronic inflammation represents a crucial risk factor for the onset and progression of tumoral lesions in individuals genetically predisposed to CRC.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/32340123/