Peer-reviewed veterinary case report
Working memory in the Ts65Dn mouse, a model for Down syndrome.
- Journal:
- Behavioural brain research
- Year:
- 2006
- Authors:
- Dowdy-Sanders, Nichole C & Wenger, Galen R
- Affiliation:
- University of Arkansas Medical Sciences · United States
- Species:
- rodent
Abstract
This study used a matching-to-position schedule of reinforcement to examine working memory in Ts65Dn and littermate control mice. Initially there appeared to be a memory deficit in the Ts65Dn mice, which disappeared with extended practice. Thus, what appeared as a memory deficit may actually be the result of a delay in learning the concept of matching. These results suggest that delayed learning may be an important factor in other procedures examining working memory in Ts65Dn mice and have important implications for clinical treatment of Down syndrome patients.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16386318/