Peer-reviewed veterinary case report
World association for the advancement of veterinary parasitology (WAAVP): second edition of guidelines for evaluating the efficacy of equine anthelmintics.
- Journal:
- Veterinary parasitology
- Year:
- 2002
- Authors:
- Duncan, J L et al.
- Affiliation:
- Faculty of Veterinary Medicine · United Kingdom
- Species:
- horse
Plain-English summary
These new guidelines are meant to help researchers and regulatory bodies evaluate how effective certain medications are against internal parasites in horses. While the focus is on anthelmintics (medications that kill worms), the guidelines also cover treatments for larvae of horse bot flies, which are a different type of parasite that can affect a horse's stomach. The document discusses the pros and cons of different testing methods and provides advice on how to choose the right horses for studies, their living conditions, feeding, and how to keep accurate records. Overall, these guidelines aim to ensure that studies are done in a consistent way while using the fewest animals necessary.
Abstract
These guidelines have been designed to assist in the planning, operation and interpretation of studies which would serve to assess the efficacy of drugs against internal parasites of horses. Although the term anthelmintic is used in the title and text, these guidelines include studies on drug efficacy against larvae of horse bot flies, Gasterophilus spp., which are non-helminth parasites commonly occurring in the stomach of horses. The advantages, disadvantages and application of critical and controlled tests are presented. Information is also provided on selection of animals, housing, feed, dose titration, confirmatory and clinical trials, record keeping and necropsy procedures. These guidelines should assist both investigators and registration authorities in the evaluation of compounds using comparable and standard procedures with the minimum number of animals.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/11750996/