Peer-reviewed veterinary case report
X-linked severe combined immunodeficiency in Cardigan Welsh corgi
By Pullen, R P et al.·Published in Journal of the American Animal Hospital Association·1997·School of Veterinary Medicine, United States·View original on PubMed →
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Original publication title: X-linked severe combined immunodeficiency in a family of Cardigan Welsh corgis.
- Species:
- dog
Plain-English summary
Two male Cardigan Welsh corgi puppies were affected by a serious immune system problem called X-linked severe combined immunodeficiency (XSCID). One puppy had to be euthanized before tests could be done, but the second puppy was tested as soon as it was discovered that they were related and was quickly getting worse. The tests showed that this puppy had the same genetic issue as XSCID-affected basset hounds. By identifying the genetic mutation, the breeders could take steps to prevent future puppies from being affected by this condition.
People also search for: corgi puppy immune system problem · XSCID in dogs · genetic testing for dog breeding
Abstract
Two, male, Cardigan Welsh corgi puppies, one of which was diagnosed with X-linked severe combined immunodeficiency (XSCID), are described in this report. The first puppy was euthanized before definitive immunological testing could be performed. When the second puppy was presented and the relationship between the two was discovered, immunological testing was pursued immediately due to this puppy's rapid deterioration. The immunological test results and genetic studies were compared to the XSCID basset hounds and found to be similar. By unveiling the mutation, the pedigree could be analyzed and the carrier females removed from the breeding population.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/9358416/