Peer-reviewed veterinary case report
Infertile Siamese female cat with male traits has X monosomy
By Szczerbal, I et al.·Published in Reproduction in domestic animals = Zuchthygiene·2015·Department of Genetics and Animal Breeding·View original on PubMed →
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Original publication title: X monosomy in a virilized female cat.
- Species:
- cat
Plain-English summary
A Siamese female cat was brought in because she had unusual external genitalia and was displaying masculine behavior. Tests showed she had high estrogen and some testosterone levels, which are not typical for females. During surgery, her reproductive organs were removed, and further tests revealed she had a genetic condition called X monosomy, meaning she was missing one X chromosome. This case suggests that X monosomy can lead to male-like traits in female cats, even without the SRY gene, which usually determines male characteristics.
People also search for: female cat with male traits · Siamese cat ambiguous genitalia · cat hormonal imbalance treatment
Abstract
An infertile Siamese female cat was subjected for clinical, histological, cytogenetic and molecular studies due to ambiguous external genitalia (vulva, vagina, rudimentary penis and scrotum-like structure) and masculine behaviour. An elevated oestrogen activity and a detectable level of testosterone were found. The cat underwent laparotomy. The gonads and the uterus were removed and subjected for histological studies, which showed ovaries with corpora lutea and a some primordial follicles. Chromosome studies of lymphocyte and fibroblast cultures, with the use of Giemsa staining, G-banding and whole X chromosome painting by fluorescence in situ hybridization, revealed pure X monosomy. Molecular analysis showed the absence of the SRY gene. Our study revealed for the first time that X monosomy in cats may be associated with virilization, in spite of the lack of the SRY gene.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25611903/