Peer-reviewed veterinary case report
X monosomy in the endangered Kiso horse breed detected by a parentage test using sex chromosome linked genes and microsatellites.
- Journal:
- The Journal of veterinary medical science
- Year:
- 2019
- Authors:
- Gamo, Shiori et al.
- Affiliation:
- Department of Veterinary Medicine · Japan
- Species:
- horse
Plain-English summary
A routine parentage test for a 7-month-old Kiso horse filly, which is an endangered breed, revealed a possible issue with her sex chromosomes. Further testing showed that she did not inherit an X chromosome from her father, confirming a condition known as X monosomy, where she has only one X chromosome instead of the usual two. Because this condition is likely to make her unable to have foals, the decision was made not to use her for breeding. This information is important for horse owners to avoid misunderstandings when transferring ownership of the filly.
Abstract
A routine parentage test as part of a conservation program for Kiso horses identified a possible sex chromosome anomaly in a 7 months-old filly because of an aberrant result using LEX3, an X-linked marker. We then analyzed X-linked markers (LEX26, TKY38, and TKY270), Y-linked markers (Eca.YH12, Eca.YM2, Eca.YA16, and the sex-determining region Y gene), and an X/Y marker (Amelogenin gene). This analysis demonstrated that the filly had not inherited an X chromosome from her sire. A karyotyping analysis confirmed that the filly was 63,XO. As it was suspected that the horse would be sterile, we avoided using the horse as a broodmare; the information should also serve to prevent unnecessary conflict between owners transferring and receiving the horse.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/30473577/