Peer-reviewed veterinary case report
α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria.
- Journal:
- Nature medicine
- Year:
- 2017
- Authors:
- Zee, Tiffany et al.
- Affiliation:
- Department of Urology · United States
Abstract
Cystinuria is an incompletely dominant disorder characterized by defective urinary cystine reabsorption that results in the formation of cystine-based urinary stones. Current treatment options are limited in their effectiveness at preventing stone recurrence and are often poorly tolerated. We report that the nutritional supplement α-lipoic acid inhibits cystine stone formation in the Slc3a1mouse model of cystinuria by increasing the solubility of urinary cystine. These findings identify a novel therapeutic strategy for the clinical treatment of cystinuria.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/28165480/