Peer-reviewed veterinary case report
Xanthine bladder stones in Dalmatians treated with allopurinol
By Ling, G V et al.·Published in Journal of the American Veterinary Medical Association·1991·Department of Medicine, United States·View original on PubMed →
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Original publication title: Xanthine-containing urinary calculi in dogs given allopurinol.
- Species:
- dog
Plain-English summary
Ten dogs, mostly Dalmatians, developed urinary stones made of xanthine while being treated with allopurinol, a medication often used to manage uric acid levels. These dogs had a history of forming uric acid stones before starting allopurinol, and the stones were difficult to identify using standard testing methods. The best way to diagnose these xanthine stones was through a specialized test called high-pressure liquid chromatography, which can accurately detect small amounts of the crystals. It's important for pet owners to be aware of this potential issue if their dog is on allopurinol.
People also search for: dog urinary stones treatment · allopurinol side effects in dogs · Dalmatians and urinary stones
Abstract
Clinical features and laboratory findings were evaluated in 10 dogs that formed xanthine-containing urinary calculi during the period that they were given allopurinol (9 to 38 mg/kg of body weight/d). Duration of allopurinol treatment was 5 weeks to 6 years. Of the 10 dogs, 9 (all Dalmatians) had formed uric acid-containing calculi at least once before allopurinol treatment was initiated. It was not possible to recognize xanthine as a crystalline component of the calculi by use of a chemical colorimetric method or by polarized light microscopy. We concluded that the best diagnostic method for recognition of xanthine-containing calculi was high-pressure liquid chromatography because it is quantitative, sensitive, and accurate, and can be conducted on a small amount (1 to 2 mg) of crystalline material.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/1874670/