Peer-reviewed veterinary case report
Xanthogranulomatous inflammation causing small bowel nodules in a dog
By Romanucci, M et al.·Published in Veterinary pathology·2008·Department of Comparative Biomedical Sciences, Italy·View original on PubMed →
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Original publication title: Xanthogranulomatous inflammation of the small bowel in a dog.
- Species:
- dog
Plain-English summary
A 12-year-old male American Staffordshire Terrier was brought in with yellow-white nodules on his small intestine, which were causing inflammation. The vet found that these nodules were made up of foamy cells and were associated with areas of tissue damage and bleeding. After examining the tissue samples, the vet determined that the dog had xanthogranulomatous inflammation, a condition that can affect the intestines. Treatment options typically include managing the inflammation and any underlying issues, but the specific outcome for this dog wasn't detailed.
People also search for: dog small bowel inflammation · American Staffordshire Terrier intestinal issues · dog yellow nodules on intestine
Abstract
A case of xanthogranulomatous inflammation of the small bowel in a 12-year-old male American Staffordshire Terrier is described. Disseminated yellow-white nodules 2 to 3 mm in diameter bulging on the serosal surface of the small bowel, as well as on mesenteric tissue, were detected. Histopathologic examination revealed a nodular collection of foamy cells, mainly involving serosal and muscular layers, associated with necrotic areas, hemorrhages, neovascularization, variable numbers of reactive spindle cells, neutrophils, lymphocytes, plasma cells, and rare multinucleated giant cells. Transmural lymphangectasia and mucosal lymphoplasmacytic inflammation were also observed. Both Oil Red O stain and ultrastructural study revealed lipid droplets in the cytoplasm of foamy cells. Lysozyme immunoreactivity was detected in single as well as in clustered foamy cells, while smooth muscle actin was positive in spindle cells and scattered foamy elements. Lymphangectasia associated with lymphoplasmacytic enteritis suggests a component of lymphatic fluid stasis in the pathogenesis of such lesions.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18424836/