Peer-reviewed veterinary case report
Y75B8A.8 (HC8) protein of Haemonchus contortus: A functional inhibitor of host IL-2.
- Journal:
- Parasite immunology
- Year:
- 2019
- Authors:
- Wang, Wenjuan et al.
- Affiliation:
- College of Veterinary Medicine · China
Abstract
Interleukin 2 (IL-2) is an important immune regulatory factor in the immune response of the host. However, little is known about the inhibitor of host IL-2 in Haemonchus contortus infection. In this study, we found that globin domain-containing protein (HCGB) and Protein Y75B8A.8 (HC8) from H contortus excretory and secretory products are two binding proteins of IL-2 in goats. The yeast two-hybrid screening further validated the positive interactions of IL-2 with HCGB and HC8. Meanwhile, we found that HC8 had inhibitory effects on IL-2-induced peripheral blood mononuclear cell (PBMC) proliferation, while HCGB did not. Furthermore, transcriptional analysis revealed that HC8 could block the IL-2-activated signalling pathway. Our results showed that HC8 was a functional inhibitor of goat IL-2.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/30883834/