Peer-reviewed veterinary case report
Yeast nucleotides help skin cell growth and ease atopic dermatitis
By Segarra, Sergi et al.·Published in International journal of molecular sciences·2024·R&D Bioiberica S.A.U., Spain·View original on PubMed →
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Original publication title: Yeast-Derived Nucleotides Enhance Fibroblast Migration and Proliferation and Provide Clinical Benefits in Atopic Dermatitis.
- Species:
- dog
Plain-English summary
A group of dogs with atopic dermatitis (a skin allergy) were given a supplement containing a mix of nucleotides, hyaluronic acid, dermatan sulfate, and omega-3 fatty acids to see if it would help with their itching and skin health. After 30 days of treatment, the dogs showed a significant reduction in itching without any side effects. This combination of ingredients appears to be a promising option for improving skin conditions in dogs.
People also search for: dog itching treatment · atopic dermatitis in dogs · omega-3 for dog skin health
Abstract
Nucleotides, glycosaminoglycans, and omega-3 essential fatty acids (O3s) could be used for improving skin health, although their modes of action, alone or in combination, are not yet fully understood. To gain some insight into these mechanisms, we performed two in vitro tests and one in vivo pilot trial. The effects on human dermal fibroblast proliferation and migration were evaluated with the following compounds and combinations: 0.156 mg/mL O3s, 0.0017 mg/mL hyaluronic acid (HA), 0.0004 mg/mL dermatan sulfate (DS), 0.0818 mg/mL nucleotides, and [O3s + HA + DS] and [O3s + HA + DS + nucleotides] at the same concentrations. In both in vitro assays, adding nucleotides to [O3s + HA + DS] provided significant improvements. The resulting combination [O3s + HA + DS + nucleotides] was then tested in vivo in dogs with atopic dermatitis by oral administration of a supplement providing a daily amount of 40 mg/kg nucleotides, 0.9 mg/kg HA, 0.18 mg/kg DS, 53.4 mg/kg EPA, and 7.6 mg/kg DHA. After 30 days, the pruritus visual analog scale (pVAS) score was significantly reduced, and no adverse effects were observed. In conclusion, the combination of nucleotides plus glycosaminoglycans and O3s could serve as a useful therapeutic alternative in skin health applications.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38474135/