Peer-reviewed veterinary case report
Yeast Prion Protein Sup35 Initiates α-Synuclein Pathology in Parkinson's Disease.
- Journal:
- Movement disorders : official journal of the Movement Disorder Society
- Year:
- 2024
- Authors:
- Wang, Youcui et al.
- Affiliation:
- Institute of Brain Science and Disease · China
- Species:
- rodent
Abstract
Sinus infection of Saccharomyces cerevisiae accelerates the aggregation of α-synuclein (α-syn) in A53T mice, which was caused by prion protein Sup35. Sup35 promotes α-syn aggregation in vitro and in vivo and leads to Parkinson's disease (PD)-like motor impairment in wildtype mice, suggesting that the yeast Sup35 triggers α-syn pathology in PD.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/38627965/