Peer-reviewed veterinary case report
Young blood for old kidneys? More questions than answers so far.
- Journal:
- Kidney international
- Year:
- 2018
- Authors:
- Plotkin, Matthew
- Affiliation:
- University of Arkansas for Medical Sciences · United States
Abstract
The aging kidney has increased susceptibility to injury and decreased regenerative capacity. It is unknown if the effects of aging on acute kidney injury are reversible. In this issue, Liu et al., using a mouse heterochronic parabiosis ischemia-reperfusion model, demonstrate that a shared circulation between a young and older mouse results in decreased acute tubular injury. This study is an important first step using an interesting model, but many questions remain about how young blood reduces acute kidney injury in an older mouse.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/30031441/