Peer-reviewed veterinary case report
A Canine Surgical Model of Stroke by Minimally Invasive Occlusion of the Proximal Middle Cerebral Artery.
- Journal:
- Bulletin of experimental biology and medicine
- Year:
- 2023
- Authors:
- Liu, J et al.
- Affiliation:
- Department of Neurosurgery · China
- Species:
- dog
Plain-English summary
In this study, researchers created a model of ischemic stroke (a type of stroke caused by a lack of blood flow to the brain) using 10 beagle dogs. They used a minimally invasive surgical technique to block a specific artery in the brain, which allowed them to study the effects of this blockage. The dogs were divided into two groups: one group had the surgery without actually blocking the artery, while the other group had the artery permanently blocked. The researchers used various tests, including brain scans and behavior assessments, to observe the effects of the blockage, which confirmed that the model accurately represented the brain damage seen in strokes. This model is expected to help improve research on stroke treatments in the future.
Abstract
In this study, a model of ischemic stroke by surgical proximal middle cerebral artery (MCA) occlusion was developed on 10 beagle dogs. The advantages of this model are the transtemporal approach and a minimally invasive surgical procedure. Dogs were randomly assigned to two groups: sham-operated (proximal MCA exposure without occlusion) and experimental (permanent proximal MCA occlusion) groups. Different evaluation methods were used to assess the consequences of MCA occlusion in dogs, including neurobehavioral tests, MRI, and immunohistochemical staining. Clear signs of cerebral infarction associated with the region supplied by MCA were confirmed and the model showed good repeatability and consistency. The model can serve as an appropriate large animal model to improve the translation of stroke therapeutics research from the laboratory to the clinical practice.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/36735113/