Peer-reviewed veterinary case report
Dog with kidney lymphoma and severe high red blood cell count
By Kotb, Sara et al.·Published in BMC veterinary research·2021·Carlson College of Veterinary Medicine, United States·View original on PubMed →
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Original publication title: A case of canine renal lymphoma of granular lymphocytes with severe polycythemia.
- Species:
- dog
Plain-English summary
A 10-year-old Labrador retriever was brought to the vet after showing signs of increased thirst and urination for a month, along with a swollen belly, tiredness, and trouble breathing for two weeks. An ultrasound revealed a mass in the left kidney, and tests confirmed it was a type of cancer called renal lymphoma, specifically a rare form involving T-cells. The dog also had a very high red blood cell count, known as severe polycythemia. Unfortunately, renal lymphoma is rare and often has a poor prognosis, so the outcome for this dog was not favorable.
People also search for: dog kidney cancer symptoms · Labrador polycythemia treatment · dog lymphoma prognosis
Abstract
BACKGROUND: Renal lymphoma in dogs is rare and has a poor prognosis. Granular lymphocyte morphology is rarely reported in canine renal lymphoma. Mild to moderate polycythemia is reported in a number of canine renal lymphoma cases. CASE PRESENTATION: A 10-year-old Labrador retriever presented to a university veterinary teaching hospital after a 1-month history of polyuria, polydipsia, and pollakiuria and a 2-week history of abdominal distention, lethargy, and increased respiratory effort. Abdominal ultrasound showed a wedge-shaped to rounded, heterogeneously hypoechoic mass lesion in the left kidney. Cytologic analysis of a percutaneous aspirate of the mass was consistent with lymphoma of granular lymphocytes. Severe polycythemia (hematocrit 0.871) was noted on a complete blood cell count. Clonality analysis identified a clonally rearranged T-cell receptor (TCR) gene and immunohistochemical staining was CD3+, CD79a- and CD11d+, supporting cytotoxic T-cell lymphoma. CONCLUSIONS: To our knowledge, this is the first report of renal cytotoxic T-cell lymphoma with severe polycythemia in a dog. Severe polycythemia and renal cytotoxic T-cell lymphoma are both rare in dogs; this report adds to the body of knowledge on these conditions.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33853604/