Peer-reviewed veterinary case report
Dog with Cushing's disease later diagnosed with chronic lymphocytic
By Choi, Ju-Won et al.·Published in The Journal of veterinary medical science·2021·Department of Veterinary Internal Medicine, South Korea·View original on PubMed →
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Original publication title: A case of chronic lymphocytic leukemia masked by Cushing's disease in a dog.
- Species:
- dog
Plain-English summary
A 12-year-old female dog was brought in for excessive urination and thirst, along with a swollen belly. Tests showed she had Cushing's disease, which was treated successfully with medication. However, after her Cushing's symptoms improved, she developed low red blood cell counts and high lymphocyte levels, leading to a diagnosis of chronic lymphocytic leukemia (CLL). Chemotherapy helped reduce the lymphocyte levels, but unfortunately, her quality of life declined, and she was euthanized about 10 months after her initial visit.
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Abstract
A 12-year-old, 3.5-kg, intact female dog was presented with polyuria, polydipsia, and a pendulous abdomen. Laboratory examinations showed elevated hepatobiliary enzyme levels and neutrophilic leukocytosis. The adrenocorticotropic hormone stimulation test confirmed hyperadrenocorticism (HAC). Trilostane therapy managed the clinical condition and cortisol concentration. However, lymphocytosis and nonregenerative anemia developed after HAC remission. Bone marrow aspiration analysis revealed a lymphoproliferative disorder with a clonal T-cell population. Accordingly, the patient was diagnosed with T-cell chronic lymphocytic leukemia (CLL) and concurrent HAC. Thereafter, chemotherapy was initiated, which improved the lymphocytosis. However, euthanasia was performed because of worsening quality of life at 45 weeks after the first presentation. These results suggested that CLL could be masked by excessive endogenous cortisol and discovered after HAC remission.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34039785/