Peer-reviewed veterinary case report
Fatal toxoplasmosis in cat treated with cyclosporin A for atopy
By Last, Robert D et al.·Published in Veterinary dermatology·2004·Vetdiagnostix-Veterinary Pathology Services·View original on PubMed →
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Original publication title: A case of fatal systemic toxoplasmosis in a cat being treated with cyclosporin A for feline atopy.
- Species:
- cat
Plain-English summary
A 4-5-year-old male Domestic Short Hair cat was diagnosed with a severe case of systemic toxoplasmosis after being treated for skin allergies with cyclosporine A for eight months. The immunosuppressive effects of cyclosporine A may have made the cat more vulnerable to this infection, leading to serious liver and pancreas damage. Unfortunately, despite veterinary care, the cat did not survive. This case highlights the potential risks of using cyclosporine A in cats, particularly regarding their susceptibility to infections like toxoplasmosis.
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Abstract
Acute systemic toxoplasmosis was diagnosed in a 4-5-year-old, male, Domestic Short Hair cat, which had been on cyclosporine A immunomodulatory therapy for feline atopy, over an 8-month period. Cyclosporin A (CsA) has shown promising results as a immunosuppressive agent in the cat for the treatment of eosinophilic plaque and granulomas, allergic cervico-facial pruritus, feline atopy and other immune-mediated dermatoses. However, inhibition of T-lymphocyte function by CsA is believed to have predisposed this cat to the development of a newly acquired, acute Toxoplasma gondii infection, as characterized by severe hepatic and pancreatic pathology in conjunction with the heavy parasite load demonstrated on immunohistochemical (IHC) stains for T. gondii. Cats on CsA therapy appear to be at risk of developing fatal systemic toxoplasmosis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15214957/