Peer-reviewed veterinary case report
Cat with rapid painful swollen mammary tumor and skin redness
By Millanta, Francesca et al.·Published in Journal of Feline Medicine and Surgery·2012·Department of Animal Pathology, Prophylaxis and Food Hygiene, Faculty of Veterinary Medicine, University of Pisa, Italy, Italy·View original on Crossref →
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Original publication title: A case of feline primary inflammatory mammary carcinoma: clinicopathological and immunohistochemical findings
- Species:
- cat
Plain-English summary
A 10-year-old female cat presented with swelling, redness, and pain in her groin area, along with a skin lesion that looked like a pustule or nodule. After examining her, the vet found a malignant tumor in the breast tissue. Unfortunately, the cancer had already spread to nearby lymph nodes and other areas of her body. The tumor was found to be negative for common hormone receptors, which can affect treatment options. Sadly, due to the aggressive nature of the cancer, the prognosis was poor.
People also search for: cat breast cancer symptoms · feline mammary tumor treatment · why is my cat's belly swollen
Abstract
The clinicopathological and immunohistochemical findings of a primary feline mammary tumour with features similar to human and canine primary inflammatory carcinoma are described for the first time. The cat presented to the clinic for the rapid onset of oedema, severe erythema, local pain and warmth of the inguinal region, with a pustular-to-nodular cutaneous lesion in association with an ill-defined underlying mass. An epithelial malignant tumour was diagnosed by cytological investigation. Necropsy revealed a thickening of the skin with oedema of the subcutis in the right inguinal area, and regional and distant metastases. Histology showed an unencapsulated tubulopapillary proliferation of malignant epithelial cells, with a massive embolisation in the dermal lymphatics and a mild inflammatory infiltrate. Through immunohistochemistry, the tumour was found to be oestrogen (ER)-alpha-, androgen (AR)- and progesterone (PR)-negative; neoplastic cells were ER-alpha, AR-negative and focally PR-positive. An irregular, mild and focal HER-2 immunoreactivity was present (score +1, non-HER-2 overexpressing). The neoplastic cells were cyclo-oxygenase-2 and vascular endothelial growth factor positive.
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Search related cases →Original publication on Crossref: https://doi.org/10.1177/1098612x12442600