Peer-reviewed veterinary case report
Cat with rapid swelling and redness from inflammatory mammary cancer
By Millanta, Francesca et al.·Published in Journal of feline medicine and surgery·2012·Department of Animal Pathology, Italy·View original on PubMed →
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Original publication title: A case of feline primary inflammatory mammary carcinoma: clinicopathological and immunohistochemical findings.
- Species:
- cat
Plain-English summary
A 10-year-old female cat presented with swelling, redness, pain, and warmth in the groin area, along with a skin lesion that looked like pustules or nodules. The veterinarian found a malignant tumor in the mammary tissue, which had spread to nearby lymph nodes and other areas. Unfortunately, the cat had a serious type of cancer called primary inflammatory mammary carcinoma, which is rare in cats. Treatment options were not detailed, but early detection and intervention are crucial for better outcomes in similar cases.
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Abstract
The clinicopathological and immunohistochemical findings of a primary feline mammary tumour with features similar to human and canine primary inflammatory carcinoma are described for the first time. The cat presented to the clinic for the rapid onset of oedema, severe erythema, local pain and warmth of the inguinal region, with a pustular-to-nodular cutaneous lesion in association with an ill-defined underlying mass. An epithelial malignant tumour was diagnosed by cytological investigation. Necropsy revealed a thickening of the skin with oedema of the subcutis in the right inguinal area, and regional and distant metastases. Histology showed an unencapsulated tubulopapillary proliferation of malignant epithelial cells, with a massive embolisation in the dermal lymphatics and a mild inflammatory infiltrate. Through immunohistochemistry, the tumour was found to be oestrogen (ER)-alpha-, androgen (AR)- and progesterone (PR)-negative; neoplastic cells were ER-alpha, AR-negative and focally PR-positive. An irregular, mild and focal HER-2 immunoreactivity was present (score +1, non-HER-2 overexpressing). The neoplastic cells were cyclo-oxygenase-2 and vascular endothelial growth factor positive.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22408148/