Peer-reviewed veterinary case report
Horse with immune eye disease that turned into B-cell lymphoma
By Lisankis, Anthony P. et al.·Published in Equine Veterinary Education·2022·Eye Care for Animals Annapolis Maryland USA, United States·View original on Crossref →
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Original publication title: A case of malignant transformation of equine immune‐mediated keratitis to B‐cell lymphoma
- Species:
- horse
Plain-English summary
A 13-year-old Thoroughbred/Oldenburg gelding was referred to a specialist after developing corneal and limbal nodules due to a long-standing eye condition called immune-mediated keratitis. The vet performed surgery to remove the affected areas and found signs of a serious condition called large B-cell lymphoma during further testing. After the surgery, the horse was given a short course of eye ointment but no other treatments were needed. Eighteen months later, the horse is still comfortable and has maintained its vision without any medications.
People also search for: horse eye problems · equine lymphoma treatment · immune-mediated keratitis in horses
Abstract
Summary A 13‐year‐old Thoroughbred/Oldenburg gelding presented as a tertiary referral for a 6‐year history of immune‐mediated keratitis (IMMK) after the development of corneal and limbal nodules in the presence of medical therapy. A keratectomy extending to the limbus was performed to remove the affected cornea and limbal nodules. Two corneal‐limbal samples were submitted for histopathology and initially diagnosed as marked lympho‐histiocytic stromal keratitis with epithelial hyperplasia, keratinisation and keratinocyte apoptosis consistent with IMMK. Additional testing with immunohistochemical staining for CD3, CD20, PAX5 and IBA1 revealed large, atypical B‐lymphocytes on a background of histiocytes and mature T‐lymphocytes, with concern for T‐cell‐rich large B‐cell lymphoma. PCR antigen receptor rearrangement clonality testing was also performed and was diagnostic for large B‐cell lymphoma. Polymerase chain reaction (PCR) for equine herpesvirus 5 (EHV‐5) was positive. Following keratectomy, a short course of neomycin/polymyxin B/dexamethasone ophthalmic ointment was prescribed; no other treatment nor adjunct therapy was performed. Eighteen months post‐operation, the case remains visual and comfortable on no medications.
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Search related cases →Original publication on Crossref: https://doi.org/10.1111/eve.13725