Peer-reviewed veterinary case report
Seizures and brain inflammation in a 3-year-old female pug dog
By Hinrichs, U et al.·Published in Tierarztliche Praxis·1996·Institut fü, Germany·View original on PubMed →
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Original publication title: [A case of necrotizing meningoencephalitis in a pug dog (pug dog encephalitis--PDE)].
- Species:
- dog
Plain-English summary
A 3-year-old female pug was euthanized after suffering from repeated seizures. A thorough examination of her brain revealed severe damage and inflammation, which are typical signs of pug dog encephalitis (PDE), a serious and poorly understood condition affecting this breed. Unfortunately, there are no known effective treatments for PDE, and the prognosis is often poor once symptoms appear. This case highlights the need for awareness of this disease in pugs, especially if they start having seizures.
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Abstract
A three-year-old female pug dog was euthanized because of recurrent seizures. Pathological examination revealed severe multifocal necrosis confined to the cerebrum. Histologically, areas of malacia of different stages, with prominent gitter cell infiltration were observed. Furthermore, there was severe rarefication resulting in cavities separated by tissue bridges and blood vessels. In the adjacent tissue and in the meninges a moderate to severe non-purulent meningoencephalitis was evident. The lesions are consistent with those reported for pug dog encephalitis (PDE). In the present paper, the first case of PDE in Germany is described and an overview of the clinical symptoms, the neuropathological findings of this etiologically unknown disease, the differential diagnoses and the possible pathogenesis is given.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/8999597/