Peer-reviewed veterinary case report
Cat with eye inflammation and brain lymphoma diagnosis
By Giordano, Cristina et al.·Published in Veterinary ophthalmology·2013·Italy Department of Veterinary Pathology, Italy·View original on PubMed →
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Original publication title: A case of oculo-cerebral B-cell lymphoma in a cat.
- Species:
- cat
Plain-English summary
A 13-year-old male Persian cat was brought in with eye problems, including inflammation and high pressure in the left eye. The owner chose to have the eye removed, and after surgery, the cat showed signs of not eating, being cold, and acting aggressively. Unfortunately, the cat was euthanized, and further examination revealed that he had a type of cancer called B-cell lymphoma affecting both the eye and brain. This case is notable as it appears to be the first documented instance of this specific type of lymphoma in a cat.
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Abstract
PURPOSE: To describe a case of a cat with primary B-cell lymphoma affecting the eye and brain and which shared features similar to oculo-cerebral lymphoma in humans. METHODS: A 13-year-old castrated male Persian cat presented with clinical signs of anterior uveitis and increased intraocular pressure (IOP) in the left eye (OS). A complete diagnostic work-up was declined, and left-eye enucleation was performed. The globe was submitted for histopathology. One week after surgery, the cat became inappetent, hypothermic, and aggressive. Euthanasia was requested by the owner, and a necropsy was permitted. RESULTS:   Histopathology of the enucleated globe revealed an extensive neoplastic infiltration consistent with large-cell lymphoma, affecting the anterior uvea, neuroretina and optic nerve. At necropsy, all organs were unremarkable except for the brain, where there was a neoplastic cell population consistent with that described in the left eye, infiltrated and expanded meninges, and perivascular spaces. Immunohistochemically, the neoplastic cells were positive for B-cell marker (CD20) and negative for T-cell marker (CD3). Histology and immunophenotyping suggested a diagnosis of primary central nervous system and ocular large B-cell lymphoma. DISCUSSION: The lymphoma in this cat resembled oculo-cerebral lymphoma in humans, sharing similar clinical features and histopathological findings, including the perivascular pattern of neoplastic cell infiltration. To the best of the authors' knowledge, this is the first description of a primary oculo-cerebral B-cell lymphoma in a cat.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22520020/