Peer-reviewed veterinary case report
English bulldog with heart failure caused by rare heart lymphoma
By Köster, Liza S et al.·Published in Frontiers in veterinary science·2024·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: A case report: Null-cell cardiac lymphoma in an English bulldog.
- Species:
- dog
Plain-English summary
A middle-aged English bulldog showed signs of right heart failure, which can include difficulty breathing and lethargy. An ultrasound of the heart revealed thickened heart walls and fluid around the heart, raising concerns about a serious condition. Unfortunately, the owner chose to euthanize the dog, and a post-mortem examination revealed high-grade lymphoma in the heart muscle. This type of cancer was not typical for T-cells or B-cells, indicating a rare form of lymphoma.
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Abstract
This case report describes a novel example of an extranodal null-type lymphoma in the myocardium of a middle-aged English bulldog who presented with signs of right heart failure. An echocardiogram found, in addition to the pericardial effusion, thickened right and left ventricular free walls and the interventricular septum. The right ventricular free wall myocardium had multinodular lesions, suspicious for infiltrative disease. The owner elected humane euthanasia, and permission for necropsy was obtained. Multifocal left and right ventricular nodules and an incidental aortic root mass were detected, the latter of which was later confirmed as a chemodectoma. Microscopically, the myocardial nodules were sheets of round cells consistent with a high-grade lymphoma. Neoplastic cells were not immunoreactive to CD3 (T-cell) or CD20 and CD79a (B-cell), Mum-1 (plasma cell), CD117 (mast cell), or CD18 (histiocyte). These findings are consistent with a high-grade, null-cell-type lymphoma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38384958/