Peer-reviewed veterinary case report
Personalized dasatinib treatment for dog with osteosarcoma
By Davis, Lara E et al.·Published in Pediatric blood & cancer·2013·Family Pediatric Research Institute, United States·View original on PubMed →
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Original publication title: A case study of personalized therapy for osteosarcoma.
- Species:
- dog
Plain-English summary
A 7-year-old dog with osteosarcoma (a type of bone cancer) was treated with a personalized therapy approach. After establishing a culture of the tumor cells, the vet identified a targeted medication called dasatinib as the most effective treatment. The dog received dasatinib for 26 weeks after initial chemotherapy, and follow-up tests showed no signs of cancer returning 24 months later. This case suggests that personalized treatments could be beneficial for other dogs with similar tumors.
People also search for: dog osteosarcoma treatment · dasatinib for dogs · dog cancer survival rate
Abstract
BACKGROUND: Effective targeted therapies are needed in sarcomas, but the biological heterogeneity of these tumors has presented a challenge to clinical integration of small molecule inhibitors in sarcoma treatment. Here we outline a process to personalize therapy for sarcomas through a case study of a canine with spontaneous osteosarcoma. PROCEDURE: Rapid establishment of a primary tumor cell culture is described, followed by efficient functional characterization of the tumor that identified the Src inhibitor dasatinib as the most effective targeted therapy for this individual dog. RESULTS: Adjuvant dasatinib was administered for a total of 26 weeks following treatment with chemotherapy. Pharmacokinetic studies confirm that a therapeutic serum concentration was achieved at a tolerable dose of 0.75 mg/kg/day. The canine patient remains without evidence of recurrent disease 24 months following initial diagnosis. CONCLUSIONS: The approach described through this illustrative case study is broadly applicable and might be used for other solid tumors in canines as well as in humans.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23526721/