Peer-reviewed veterinary case report
Immune responses in vaccinated and wild-type virus exposed dogs
By Perrone, Danielle et al.·Published in Canadian journal of veterinary research = Revue canadienne de recherche veterinaire·2010·Department of Veterinary Biosciences, United States·View original on PubMed →
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Original publication title: A comparison of the immune responses of dogs exposed to canine distemper virus (CDV) - Differences between vaccinated and wild-type virus exposed dogs.
- Species:
- dog
Plain-English summary
A group of dogs was tested for their immune response to the canine distemper virus (CDV), which can cause serious illness. The study looked at vaccinated dogs, shelter dogs without known vaccination history, and dogs exposed to the virus in the wild. It found that while both vaccinated and unvaccinated dogs showed some immune response, many shelter dogs were not vaccinated, raising concerns about public health. The results highlighted that dogs in areas where CDV is common had lower antibody levels compared to vaccinated dogs.
People also search for: dog distemper virus symptoms · vaccinated vs unvaccinated dog immune response · shelter dog vaccination status
Abstract
Canine distemper virus (CDV)-specific immune response was measured in different dog populations. Three groups of vaccinated or wild-type virus exposed dogs were tested: dogs with a known vaccination history, dogs without a known vaccination history (shelter dogs), and dogs with potential exposure to wild-type CDV. The use of a T-cell proliferation assay demonstrated a detectable CDV-specific T-cell response from both spleen and blood lymphocytes of dogs. Qualitatively, antibody assays [enzyme-linked immunosorbent assay (ELISA) and neutralization assay] predicted the presence of a T-cell response well, although quantitatively neither antibody assays nor the T-cell assay correlated well with each other. An interesting finding from our study was that half of the dogs in shelters were not vaccinated (potentially posing a public veterinary health problem) and that antibody levels in dogs living in an environment with endemic CDV were lower than in vaccinated animals.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20885846/