Peer-reviewed veterinary case report
Comparing sepsis definitions to predict death risk in dogs
By Turley, Kelsey et al.·Published in Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)·2023·Emergency and Critical Care, United States·View original on PubMed →
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Original publication title: A comparison of the Sepsis-2 and Sepsis-3 definitions for assessment of mortality risk in dogs with parvovirus.
- Species:
- dog
Plain-English summary
A group of 59 dogs diagnosed with parvovirus was evaluated to see which definition of sepsis (mSepsis-2 or mSepsis-3) better predicted their risk of dying. The study found that dogs classified under the mSepsis-3 criteria had a higher chance of mortality, longer hospital stays, and higher treatment costs compared to those under mSepsis-2. This suggests that using the mSepsis-3 criteria can help veterinarians identify which dogs are at greater risk and may need more intensive care. Understanding these definitions can be crucial for improving treatment outcomes for dogs with parvovirus.
People also search for: dog parvovirus treatment · signs of sepsis in dogs · how to care for a dog with parvovirus
Abstract
OBJECTIVE: To evaluate the use of a modified Sepsis-3 (mSepsis-3) definition compared to the currently used modified Sepsis-2 (mSepsis-2) definition to determine whether the mSepsis-2 or mSepsis-3 stratifications were able to identify populations of dogs ultimately more likely to die from canine parvovirus (CPV) infection. DESIGN: Retrospective, January 2009 to March 2020. SETTING: A private, small animal, urban, referral emergency and specialty hospital. ANIMALS: Fifty-nine client-owned dogs hospitalized for treatment of CPV. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Dogs were divided into mSepsis-2 and mSepsis-3 categories based on the highest level of illness severity reached during hospitalization. Greater illness severity based on mSepsis-2 criteria (ie, sepsis, severe sepsis, septic shock) was associated with an increase in average length of stay (P < 0.001), increase in average cost of stay (P < 0.01), and presence of leukopenia (P < 0.05). An increase in illness severity within the mSepsis-2 criteria was not associated with hyperlactatemia (P = 0.29), presence of neutropenia (P = 0.12), or mortality (P = 0.35). Greater illness severity based on mSepsis-3 criteria (ie, infection only, sepsis, septic shock) was associated with an increase in mortality (P < 0.05), increase in average length of stay (P < 0.001), increase in average cost of stay (P < 0.01), presence of leukopenia (P < 0.01), and presence of neutropenia (P < 0.05). The mSepsis-3 criteria were not associated with the presence of hyperlactatemia (P = 0.68). There was no significant difference between survivors and nonsurvivors in the presence of leukopenia (P = 0.19), neutropenia (P = 0.67), or hyperlactatemia (P = 0.58). CONCLUSIONS: The mSepsis-3 diagnostic criteria appear to better identify dogs with CPV at higher risk for mortality compared to the mSepsis-2 criteria.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36815748/