Peer-reviewed veterinary case report
A contusion model of severe spinal cord injury in rats.
- Journal:
- Journal of visualized experiments : JoVE
- Year:
- 2013
- Authors:
- Krishna, Vibhor et al.
- Affiliation:
- Department of Neuroscience · United States
- Species:
- rodent
Abstract
The translational potential of novel treatments should be investigated in severe spinal cord injury (SCI) contusion models. A detailed methodology is described to obtain a consistent model of severe SCI. Use of a stereotactic frame and computer controlled impactor allows for creation of reproducible injury. Hypothermia and urinary tract infection pose significant challenges in the post-operative period. Careful monitoring of animals with daily weight recording and bladder expression allows for early detection of post-operative complications. The functional results of this contusion model are equivalent to transection models. The contusion model can be utilized to evaluate the efficacy of both neuroprotective and neuroregenerative approaches.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23979022/