Peer-reviewed veterinary case report
Creating a Reproducible Model of Spinal Cord Injury in Rats: A Contusion Approach.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2024
- Authors:
- Raza, Syed Shadab
- Affiliation:
- Department of Biotechnology · India
- Species:
- rodent
Abstract
Spinal cord injury (SCI) is a devastating clinical condition that affects millions of people worldwide. SCI primarily affects males in younger age groups. It is characterized by a complex of neurological dysfunctions that can lead to permanent disability. We describe an adapted technique for SCI, i.e., a contusion model of SCI, in this chapter. This model is widely used to study the pathology of SCI and test potential therapies. The experimental contusion is performed by using a compression device, which allows the creation of a reproducible injury animal model through the definition of specific injury parameters. A detailed methodology has been developed and described here that utilizes a stereotactic frame and impactor to produce reproducible injuries.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/38427261/