Peer-reviewed veterinary case report
A CpG oligonucleotide can protect mice from a low aerosol challenge dose of Burkholderia mallei.
- Journal:
- Infection and immunity
- Year:
- 2006
- Authors:
- Waag, David M et al.
- Affiliation:
- United States Army Medical Research Institute of Infectious Diseases · United States
- Species:
- rodent
Abstract
Treatment with an oligodeoxynucleotide (ODN) containing CPG motifs (CpG ODN 7909) was found to protect BALB/c mice from lung infection or death after aerosol challenge with Burkholderia mallei. Protection was associated with enhanced levels of gamma interferon (IFN-gamma)-inducible protein 10, interleukin-12 (IL-12), IFN-gamma, and IL-6. Preexposure therapy with CpG ODNs may protect victims of a biological attack from glanders.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16495571/