Peer-reviewed veterinary case report
Unusual skin plasmacytoma tumors with gland-like patterns in older
By McHale, Brittany et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2018·Department of Pathology and Athens Veterinary Diagnostic Laboratory (McHale, United States·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: A divergent pseudoglandular configuration of cutaneous plasmacytoma in dogs.
- Species:
- dog
Plain-English summary
A group of dogs with skin tumors, specifically cutaneous plasmacytomas, were studied to understand a unique arrangement of the cancer cells. These tumors can appear in various places like the mouth, ears, and skin, and are usually not hard to identify. However, in these cases, the tumors had an unusual structure that made them look like other types of tumors, which could confuse diagnosis. The dogs were around 11 years old on average, and the tumors were found in different breeds. Treatment options typically include surgical removal, and most dogs can recover well after the procedure.
People also search for: dog skin tumor treatment · cutaneous plasmacytoma in dogs · signs of dog cancer · dog tumor diagnosis · what to do for dog skin lumps
Abstract
Cutaneous and mucocutaneous plasmacytoma (PCT) is a common neoplasm of dogs. Tumors can be single or multiple and occur predominantly in the oral cavity, lip, ears, digits, and trunk. Although these tumors typically offer no diagnostic challenge for the pathologist, subsets of PCTs with atypical morphologic configurations may make differentiation from other neoplasms difficult. We describe 6 cases of canine cutaneous and mucocutaneous PCT with pseudoglandular arrangement of neoplastic cells. The mean age of affected dogs was 11.3 y, and multiple breeds and sites were affected. Histologically, neoplastic cells were arranged in sheets, packets, and pseudoglandular structures containing central accumulations of blood or eosinophilic material admixed with neoplastic cells and hemosiderin-laden macrophages. Given the presence of pseudoglandular structures resembling neoplastic acini, epithelial neoplasia was occasionally included in the differential diagnosis. Neoplastic cells were strongly immunopositive for multiple myeloma oncogene 1 ( MUM-1) and immunonegative for pancytokeratin AE1/AE3. Canine cutaneous and mucocutaneous PCTs with pseudoglandular morphology may resemble epithelial neoplasia and raise questions about tumor histogenesis.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29153038/