Peer-reviewed veterinary case report
A functional tonB gene is required for both virulence and competitive fitness in a chinchilla model of Haemophilus influenzae otitis media.
- Journal:
- BMC research notes
- Year:
- 2012
- Authors:
- Morton, Daniel J et al.
- Affiliation:
- Department of Pediatrics · United States
- Species:
- rodent
Abstract
BACKGROUND: Haemophilus influenzae requires heme for aerobic growth and possesses multiple mechanisms to obtain this essential nutrient. METHODS: An insertional mutation in tonB was constructed and the impact of the mutation on virulence and fitness in a chinchilla model of otitis media was determined. The tonB insertion mutant strain was significantly impacted in both virulence and fitness as compared to the wildtype strain in this model. CONCLUSIONS: The tonB gene of H. influenzae is required for the establishment and maintenance of middle ear infection in this chinchilla model of bacterial disease.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22731867/