Peer-reviewed veterinary case report
Development of a chinchilla model to allow direct, continuous, biophotonic imaging of bioluminescent nontypeable Haemophilus influenzae during experimental otitis media.
- Journal:
- Infection and immunity
- Year:
- 2005
- Authors:
- Novotny, Laura A et al.
- Affiliation:
- Columbus Children's Research Institute · United States
- Species:
- rodent
Abstract
We transformed a nontypeable Haemophilus influenzae clinical isolate with a plasmid containing the luxCDABE operon driven by the H. influenzae outer membrane protein P2 promoter. Herein, we demonstrate the ability to detect bioluminescence and to monitor infection within the nasopharynges, eustachian tubes, and middle ears of chinchillas after intranasal and transbullar challenges.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15618201/