Peer-reviewed veterinary case report
A mutation in hairless dogs implicates FOXI3 in ectodermal development.
- Journal:
- Science (New York, N.Y.)
- Year:
- 2008
- Authors:
- Drögemüller, Cord et al.
- Affiliation:
- University of Berne
- Species:
- dog
Abstract
Mexican and Peruvian hairless dogs and Chinese crested dogs are characterized by missing hair and teeth, a phenotype termed canine ectodermal dysplasia (CED). CED is inherited as a monogenic autosomal semidominant trait. With genomewide association analysis we mapped the CED mutation to a 102-kilo-base pair interval on chromosome 17. The associated interval contains a previously uncharacterized member of the forkhead box transcription factor family (FOXI3), which is specifically expressed in developing hair and teeth. Mutation analysis revealed a frameshift mutation within the FOXI3 coding sequence in hairless dogs. Thus, we have identified FOXI3 as a regulator of ectodermal development.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18787161/