Peer-reviewed veterinary case report
Boxer dog lymphangiosarcoma treated with toceranib after chemo failure
By Marcinowska, A et al.·Published in The Journal of small animal practice·2013·Department of Veterinary Medicine, United Kingdom·View original on PubMed →
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Original publication title: A novel approach to treatment of lymphangiosarcoma in a boxer dog.
- Species:
- dog
Plain-English summary
A 5-year-old female boxer had a swelling near her back mammary gland, which turned out to be lymphangiosarcoma, a type of cancer. After surgery to remove the mass, she was treated with doxorubicin, which kept the cancer from coming back for six months. When it returned, other treatments didn't work well, but introducing toceranib phosphate led to almost complete disappearance of the tumor, leaving just a small skin mark. This approach helped extend her survival time significantly.
People also search for: boxer dog lump treatment · lymphangiosarcoma in dogs · toceranib phosphate for dog cancer
Abstract
A five-year-old female boxer presented with a swelling in the area of the caudal mammary gland. The mass was surgically excised and histopathological examination revealed a poorly demarcated lesion, extending into mammary tissue and infiltrating the sinuses of adjacent lymph nodes. The diagnosis was lymphangiosarcoma. Full blood work, thoracic radiographs, abdominal and scar ultrasound were unremarkable, apart from possible inflammatory reactions in the latter and reactive/metastatic changes in inguinal lymph nodes. Doxorubicin treatment resulted in a 6-month recurrence free interval. At relapse, the dog was treated with metronomic chemotherapy using chlorambucil and meloxicam, which failed to adequately control the disease. Toceranib phosphate was introduced and resulted in almost complete regression of the mass, leaving just a skin plaque. To the authors' knowledge this is the first report describing the use of two novel therapeutic approaches to treat canine lymphangiosarcoma that resulted in a higher than previously described survival time.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23560802/