Peer-reviewed veterinary case report
Dog with acute myelomonocytic leukemia showing unusual symptoms
By Graves, T K et al.·Published in Journal of the American Animal Hospital Association·1997·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: A potentially misleading presentation and course of acute myelomonocytic leukemia in a dog.
- Species:
- dog
Plain-English summary
A nine-year-old male golden retriever was brought to the vet with symptoms like extreme tiredness, fever, swollen lymph nodes, an enlarged liver and spleen, and pale gums. Blood tests showed a very high number of immature white blood cells and low red blood cells and platelets, leading to a preliminary diagnosis of acute lymphocytic leukemia. However, after starting chemotherapy typically used for lymphoma, the dog showed some improvement. Further testing revealed that he actually had acute myelomonocytic leukemia, but he still responded partially to the treatment.
People also search for: dog lethargy swollen lymph nodes · golden retriever leukemia treatment · dog chemotherapy response
Abstract
A nine-year-old, castrated male golden retriever had lethargy, fever, massive peripheral lymphadenomegaly, hepatosplenomegaly, and pale mucous membranes. There was a marked leukocytosis (456.3 x 10(3) cells/microliter) with 99% blasts; a moderate, nonregenerative anemia; and marked thrombocytopenia. A tentative diagnosis of acute lymphocytic leukemia was made pending results of cytochemical staining. Despite the severity of the laboratory and clinical findings, the dog exhibited a partial response to an induction chemotherapy protocol commonly used for lymphoma. Subsequent cytochemical staining of the original blood and bone-marrow samples resulted in a revised diagnosis of acute myelomonocytic leukemia (AML-M4). Clinicopathological findings, response to treatment, and clinical outcome in this case of canine AML-M4 are discussed.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/8974024/