Peer-reviewed veterinary case report
A potentially misleading presentation and course of acute myelomonocytic leukemia in a dog.
- Journal:
- Journal of the American Animal Hospital Association
- Year:
- 1997
- Authors:
- Graves, T K et al.
- Affiliation:
- Department of Small Animal Clinical Sciences · United States
- Species:
- dog
Plain-English summary
A nine-year-old neutered male golden retriever was very tired, had a fever, swollen lymph nodes, an enlarged liver and spleen, and pale gums. Blood tests showed a very high number of immature white blood cells, low red blood cell counts, and low platelet counts. Initially, the vet thought he might have acute lymphocytic leukemia, but after further testing, it was determined he actually had acute myelomonocytic leukemia. Despite the seriousness of his condition, the dog showed some improvement with a chemotherapy treatment typically used for lymphoma. Overall, the treatment had a partial effect on his condition.
Abstract
A nine-year-old, castrated male golden retriever had lethargy, fever, massive peripheral lymphadenomegaly, hepatosplenomegaly, and pale mucous membranes. There was a marked leukocytosis (456.3 x 10(3) cells/microliter) with 99% blasts; a moderate, nonregenerative anemia; and marked thrombocytopenia. A tentative diagnosis of acute lymphocytic leukemia was made pending results of cytochemical staining. Despite the severity of the laboratory and clinical findings, the dog exhibited a partial response to an induction chemotherapy protocol commonly used for lymphoma. Subsequent cytochemical staining of the original blood and bone-marrow samples resulted in a revised diagnosis of acute myelomonocytic leukemia (AML-M4). Clinicopathological findings, response to treatment, and clinical outcome in this case of canine AML-M4 are discussed.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/8974024/