Peer-reviewed veterinary case report
Benazepril and heparin improve kidney function in dogs
By Tenhündfeld, Jörg et al.·Published in Journal of the American Veterinary Medical Association·2009·Small Animal Clinic, Germany·View original on PubMed →
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Original publication title: A randomized controlled clinical trial of the use of benazepril and heparin for the treatment of chronic kidney disease in dogs.
- Species:
- dog
Plain-English summary
A group of 26 dogs with chronic kidney disease (a condition where the kidneys gradually lose function) were treated with either benazepril, a medication that helps improve kidney function and lower blood pressure, or a combination of benazepril and heparin, while some received a placebo. After 180 days, the dogs receiving benazepril showed significant improvements in their health, kidney function, and lower blood pressure compared to those on the placebo. However, adding heparin did not provide any extra benefits. Overall, benazepril proved to be effective for managing chronic kidney disease in dogs.
People also search for: dog chronic kidney disease treatment · benazepril for dogs · dog kidney health improvement
Abstract
OBJECTIVE: To investigate the effects of benazepril and heparin on renal function and blood pressure in dogs with chronic kidney disease. DESIGN: Randomized controlled clinical trial. ANIMALS: 26 dogs with chronic kidney disease. PROCEDURES: Dogs were randomly assigned to receive benazepril hydrochloride (0.5 mg/kg [0.23 mg/lb], PO, q 24 h; n = 10), benazepril and heparin (150 U/kg [68 U/lb], SC, q 8 h, for the first 6 days; 10), or a placebo (6) and were followed up for 180 days. RESULTS: Health status score at the end of the study (ie, day 180) was significantly higher for dogs in the 2 treatment groups than for dogs in the placebo group. In addition, glomerular filtration rate was significantly increased and the urine protein-to-creatinine ratio was significantly decreased, compared with baseline rates, at the end of the study for dogs in both treatment groups but not for dogs in the placebo group. Systolic and diastolic blood pressures were significantly decreased on day 6 for dogs in both treatment groups. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggested that administration of benazepril had beneficial effects in dogs with chronic kidney disease but that short-term administration of heparin in conjunction with benazepril did not appear to provide any additional benefit.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19366333/