Peer-reviewed veterinary case report
Dog with seizures found to have rare X chromosome mosaicism
By Noto, Nicholas T et al.·Published in Veterinary clinical pathology·2023·Department of Veterinary Clinical Medicine, United States·View original on PubMed →
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Original publication title: A rare finding of double Barr bodies and X-monosomy/X-trisomy mosaicism in a dog with presumed idiopathic epilepsy.
- Species:
- dog
Plain-English summary
A 4-year-old spayed female Border Collie was brought in for seizures that had been happening for about five months. After thorough testing, no major issues were found, and her seizures were successfully managed with a mix of anticonvulsant medications. During a follow-up, a blood test revealed unusual chromosomal findings, which had never been reported in dogs before. This case highlights how certain blood cell abnormalities can be linked to genetic issues in dogs.
People also search for: dog seizures treatment · Border Collie epilepsy · anticonvulsants for dogs · dog blood test results · what are Barr bodies in dogs
Abstract
A 4-year-old spayed female Border Collie dog presented to the Neurology and Neurosurgery service for an approximately five-month history of seizures. A complete neurodiagnostic workup was performed and did not reveal any significant abnormalities. The patient's seizures were well controlled with a combination of anticonvulsants. During a manual blood smear review at a follow-up appointment, double Barr bodies were identified in segmented neutrophils. Karyotyping revealed that the patient is mosaic for X-monosomy and X-trisomy, a finding that has never been reported in a dog and is rarely reported in people. This case demonstrates how the identification of abnormal neutrophil nuclear appendages may correlate with chromosomal abnormalities in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37448119/