Peer-reviewed veterinary case report
Canine oral plasmacytoma treatment and outcomes over 15 years
By Evenhuis, Janny V et al.·Published in Veterinary and comparative oncology·2023·James L. Voss Veterinary Teaching Hospital, United States·View original on PubMed →
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Original publication title: A retrospective study of canine oral extramedullary plasmacytoma over a 15-year period (July 2004-July 2019): Treatment, histologic parameters and clinical outcomes.
- Species:
- dog
Plain-English summary
A group of dogs with oral tumors called extramedullary plasmacytomas (EMPs) were treated at a veterinary clinic over 15 years. These tumors can be tricky, as they sometimes indicate a more serious condition like myeloma. Treatment options included surgery, chemotherapy, and radiation, and most dogs lived for about 973 days after diagnosis, although some experienced tumor progression. The study found that dogs without tumor progression had fewer signs of aggressive cancer under the microscope. Overall, while many dogs responded well to treatment, some did face challenges with their condition.
People also search for: dog oral tumor treatment · canine plasmacytoma prognosis · dog chemotherapy side effects
Abstract
A total of 45 cases of canine oral extramedullary plasmacytomas (EMPs) presented to a tertiary referral institution over a 15-year period were examined. Histologic sections of 33 of these cases were examined for histopathologic prognostic indicators. Patients underwent variable treatment including surgical intervention, chemotherapy and/or radiation therapy. Long term survival was observed in the majority of dogs with a median survival time of 973 days (2-4315 days). However, almost 1/3 of dogs had progression of plasma cell disease, including two cases with myeloma-like progression. Histologic characterization of these tumours did not reveal criteria to predict tumour malignancy. However, cases without tumour progression did not exceed 28 mitotic figures in ten 400× fields (2.37 mm). All cases with tumour related death showed at least moderate nuclear atypia. Oral EMPs may represent a local manifestation of systemic plasma cell disease or singular focal neoplasia.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36808816/