Peer-reviewed veterinary case report
Chemotherapy options and survival for dogs with high-grade T-cell
By Elliott, J & Baines, S·Published in Australian veterinary journal·2019·Willows Veterinary Centre & Referral Service, United Kingdom·View original on PubMed →
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Original publication title: A Retrospective Study of Multi-agent Chemotherapy including either Cyclophosphamide or Lomustine as Initial Therapy for Canine High-grade T-cell Lymphoma (2011-2017).
- Species:
- dog
Plain-English summary
A group of dogs diagnosed with high-grade T-cell lymphoma were treated with a combination of chemotherapy drugs, either including cyclophosphamide or lomustine, as their first treatment. All the dogs showed a positive response to the chemotherapy, but those treated with lomustine had significantly longer survival times compared to those receiving cyclophosphamide. While some dogs experienced mild side effects, such as elevated liver enzymes and low white blood cell counts, the overall results suggest that lomustine may be a better option for initial treatment in these cases.
People also search for: dog lymphoma treatment · canine chemotherapy side effects · lomustine for dogs lymphoma
Abstract
Multi-agent chemotherapy (vincristine, epirubicin and prednisolone) including either cyclophosphamide (CEOP) or lomustine (LEOP) was given as first-line chemotherapy to treatment-naïve canine lymphoma patients with measurable, high grade T-cell lymphoma (HGTCL). All patients responded to either CEOP or LEOP. Toxicity was typical of multi-agent chemotherapy protocols and 25% of dogs receiving lomustine exhibited mild-to-moderate ALT elevation and 29% grade 3 or 4 neutropenia. Median progression-free survival (100 versus 269 days) and overall survival (155 versus 327 days) were significantly higher in patients receiving LEOP compared to CEOP. Overall survival was improved for patients receiving LEOP compared to those receiving CEOP followed by lomustine-based rescue therapy. The results of this retrospective study support further evaluation of lomustine as part of first-line, multi-agent therapy for patients with HGTCL.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31328256/